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its counterpart lacking the extra oxygen atom. This last compound has recently gained much press coverage under the trade name OxyContinw. In fact it is simply a controlled-release tablet intended for treatment of chronic pain. Abusers apparently extract the active drug substance from the tablet. Oxycodone itself is probably no more addicting than any other related opiates, popular and regulatory impressions notwithstanding. The growing importance of drugs based on thebaine led to a search for an alternative supply of this alkaloid, because it is only a minor constituent of the mixture from the opium poppy. Several such strains have since been identi ed, including Papaver bracteum, whose dried sap is reported to contain as much as 26% thebaine.25 Most of the codeine used today is probably produced from thebaine rather than derived from morphine. Replacing the methyl group on the nitrogen by an allyl in this series gives naloxone,26 a compound that exhibits potent antagonist activity at opiate sites (Fig. 8). The drug shows no analgesic activity in any test systems, in contrast to the allyl derivatives of the morphine, benzomorphan, or for that matter benzazocine series. Administration of this potent antagonist quickly reverses the actions of opiates; it will in consequence precipitate withdrawal symptoms when administered to addicted individuals. Naloxone is, however, not active when taken by mouth. It had thus been proposed to combine the drug with methadone. Individuals in c# upc-a reader C# UPC-A Barcode Scanner Library - Read & Scan UPC-A Using ...
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